Possible effects of voluntary exercise intensity on anxiety-like behavior and its underlying molecular mechanisms in the hippocampus: Results from a study in Hatano rats.
Asano, H., Moriya, S., Hatakeyama, T., Kobayashi, S., Akimoto, T., Ohta, R.,
Kawaguchi, M.
Behav Brain Res. 2022 Jun 3;427:113854. doi: 10.1016/j.bbr.2022.113854. Epub 2022 Mar 19.


Toxicological effects of Tris (1,3-dichloro-2-propyl) phosphate exposure in adult male rats differ depending on the history of exposure in the neonatal period.
Akimoto, T., Kobayashi, S., Nakayama, A., Isobe, A., Abe, K.,Hatakeyama, T., Ohta, R., Yanagisawa, R., Koike, E., Suzuki, N.,Kawaguchi, M.
J Appl Toxicol. 2022. in press.


Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala. Chiba S. Okawata T., Kawakami, K., Ohta, R.,Kawaguchi, M.
Physiol Behav. 2022 Mar 1;245:113670. doi: 10.1016/j.physbeh.2021.113670. Epub 2021 Dec 8.


Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats.
Kobayashi S. , Kawano N, Miyado K,Ohta R, Akimoto T,Hatakeyama T,Kawaguchi, M.
J Vet Med Sci. 2022 Jan 24;84(1):153-156. doi: 10.1292/jvms.21-0046. Epub 2021 Dec 10.

Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice.
Yanagisawa R, Koike E, Win=Shwe TT, Kawaguchi M, Takano H.
Immunopharmacol Immunotoxicol. 2021 Oct;43(5):599-610. doi: 10.1080/08923973.2021.1959609. Epub 2021 Aug 13


Novel toxicity of tris (1,3-dichloro-2-propyl) phosphate in adult male rats.
Kobayashi, S., Abe, K., Isobe A., Nakayama, A., Akimoto, T., Hatakeyama, T., Saito, Y., Yanaisawa, R., Koike, E., Suzuki, N., Kawaguchi, M., Ohta, R.
J Appl Toxicol. 2021 Jun; 41(6):987-992. doi:10.1002/jat.4075. Epub 2020 Sep 30.

Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in Hatano rats
Horii, Y., Nakajima, S., Akieda-Asai, S., Ohta, R., Kawaguchi, M.
Physology & Behavior, 2021. Feb 1;229:113209. doi:10.1016/j.physbeh.2020.113209.

The impact ogf oral exposure to low dose tris(2-butoxyethyl)phosphate in allergic athmatic mice.
Yanagisawa, R., Koike,E., Win-Shwe,T.T., Kawaguchi,M., Takano, H.
J Appl Toxicol. 2020 Jun 4. doi: 10.1002/jat.4001. Online ahead of print.


Repressor Element 1 Silencing Transcription factor/Neuron-Restrictive Silencing Factor(REST/NRSF) in Social Stress and Depression.
Soga, T., Nakajima, S., Kawaguchi, M., Parhar, I.S.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 30:110053. doi: 10.1016/j.pnpbp.2020.110053.


The effects of 28-day early-life exposure to triphenyl phosphate (TPhP) on odor preference and sexual behavior in female rats.
Nakayama, A., Hattori, T., Isobe, A., Kobayashi, S., Suzuki, G., Takigami, H., and Kawaguchi, M.
J Appl Toxicol. 2020 Jun 22. doi: 10.1002/jat.4021. Online ahead of print


Investigating the effects of nest shading on the green turtle (Chelonia mydas) hatching phenotype in the Ogasawara islands using a field-based split clutch experiment.
Kobayashi, S., Endo, D., Kondo, S., Kitayama, C., Ogawa, R., Arai, K., Watanabe, G., Kawaguchi, M.
Journal of Experimental Zoology Part A 2020, Aug. 1-8. DOI: 10.1002/jez.2411

Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat.
Isobe, A., Shimada, T., Aburada, M., Yanagisawa, R., Sakawa, T., Nakamura, T., Himi, T., Ohta, R.
and Kawaguchi, M.
The Journal of Veterinary Medical Science 81(1): 147-154.


Relationship between motor function and ultrasonic vocalizations induced by maternal separation in rat pups.
Isobe, A. and Kawaguchi, M.
The Journal of Veterinary Medical Science Jan 15. doi: 10.1292/jvms.18-0604. [Epub ahead of print].

Male Hatano low-avoidance rats show more active sexual behavior with lower plasma testosterone than high-avoidance rats.
Nakayama, A., Okawa, H., Zheng, M., Pu, S., Watanabe, G., Ohta, R. and Kawaguchi, M.
The Journal of Veterinary Medical Science 80(7): 1179–1182.


Testing animal anxiety in rats: Effects of open arm ledges and closed arm wall transparency in elevated plus maze test
Horii, Y., McTaggart, I. and Kawaguchi, M.
Journal of Visualized Experiments (136): e56428, doi:10.3791/56428


Early-life exposure to Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) induces dose-dependent suppression of sexual behavior in male rats.
Kamishima, H.,Hattori, T. , Suzuki, G., Matsukami, H., Komine, C., Horii, Y., Watanabe, G., Oti, T., Sakamoto, H., Soga, T., Parhar, I. S., Kondo, Y., Takigami, H. and Kawaguchi, M.
Journal of Applied Toxicology 38(5): 649-55.

Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat. Komine, C., Nakajima, S., Kondo, Y., Horii, Y., Yoshida, M. and Kawaguchi, M
Journal of Applied Toxicology 37(8):996-1003.

A single neonatal injection of ethinyl estradiol impairs passive avoidance learning and reduces expression of estrogen receptor α in the hippocampus and cortex of adult female rats
Shiga, T., Nakamura, T. J., Komine, C., Goto, Y., Mizoguchi, Y., Yoshida, M., Kondo, Y. and Kawaguchi, M.
PLoS One 11 (1):e0146136.

Higher detection sensitivity of anxiolytic effects of diazepam by ledge-free open arm with opaque walled closed arm elevated plus maze in male rats.
Horii, Y. and Kawaguchi, M.
Behavioral Brain Research 294: 131-40.

Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice
Kamata, S.,Yamamoto, J.,Kamijo, K.,Ochiai, T.,Morita, T.,Yoshitomi, Y.,Hagiya, Y.,Kubota, M.,Ohkubo, R., Kawaguchi, M, Himi, T.,Kasahara, T. and Ishii, I.
Molecular Nutrition and Food Research 58(6): 1309-21.

- no publications -

Male Hatano high-avoidance rats show high aversive learning and high anxiety-like behaviors as compared to male low-avoidance rats
Horii, Y., Kawaguchi, M.,Ohta, R., Hirano, A., Watanabe, G., Kato, N., Himi, T. and Taya, K.
Experimental Animals 61(5):517-524,

- no publications -

(Befoe Kawaguchi assumed the position of Meiji University)

Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats.
Kawaguchi, M., Morohoshi, K., Imai, H., Morita, M., Kato, N. and Himi, T.
Experimental Animals 59(5):631-5. 2010.


Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats.
Kawaguchi, M., Morohoshi, K., Masuda, J., Watanabe, G., Morita, M., Imai, H., Taya, K. and Himi, T.
The Journal of Veterinary Medical Science 71(8): 1027-33. 2009.


Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats.
Kawaguchi, M., Irie, K., Morohoshi, K., Watanabe, G., Taya, K., Morita, K., Kondo, Y., Imai, H. and Himi, T.
Neuroscience Research 65(2): 136-40. 2009.


Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium.
Irie, K., Sato, T., Tanaka, I., Nakajima, J., Kawaguchi, M. and Himi, T.
Journal of Natural Medicines 63(2): 111-6. 2009.


Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor β1 and synapsin I in brain, resulting in thyroid function vulnerability in rats.
Kawaguchi, M., Morohoshi, K., Saita, E., Yanagisawa, R., Watanabe, G., Takano, H., Morita, M., Imai, H., Taya, K. and Himi, T.
Endocrine 33(3): 277-84. 2008.


Expression of nerve growth factor and its receptors trkA and p75 and inhibin alpha-subunit in the ovarian interstitial cells of lactating golden hamsters.
Weng, Q., Shi, Z.,Kawaguchi, M., Watanabe, G. and Taya, K.
Journal of Reproduction and Development 54(5): 397-401. 2008.


Bisphenol A induces transforming growth factor-beta3 mRNA in the preoptic area: a cDNA expression array and Northern blot study.
Fukushima, A., Funabashi, T., Kawaguchi, M., Mitsushima, D. and Kimura, F.
Neuroscience Letters 411(1): 81-5. 2007.


Effects of bilateral efferent duct ligation on sperm motility and secretion of FSH, LH, inhibin and testosterone in adult male rats.
Ren, L., Medan, M. S., Li, C., Weng, Q., Kawaguchi, M., Watanabe, G. and Taya, K.
Endocrine 30(2): 151–60. 2006.


Effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary functions in adult ovariectomized rats.
Furuta, M., Funabashi, T., Kawaguchi, M., Nakamura, T. J., Mitsushima, D. and Kimura, F.
Neuroendocrinology 84(1): 14-20. 2006.


Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia.
Kawaguchi, M., Scott, K. A., Moran, T. H. and Bi, S.
American journal of physiology. Regulatory, integrative and comparative physiology 288(6): R1800–5. 2005


Expression of nerve growth factor (NGF), and its receptors TrkA and p75 in the reproductive organs of the adult male rats.
Li, C., Watanabe, G., Weng, Q., Jin, W., Furuta, C., Suzuki, A. K.,Kawaguchi, M.and Taya, K.
Zoological Science 22: 933-37. 2005.


Induction of superovulation by immunoneutralization of endogenous inhibin in immature rats.
Ishigame, H., Medan, M. S., Kawaguchi, M., Fukuda, J., Watanabe, G., Arai, K. Y. and Taya, K.
Journal of Reproduction and Development 51(5): 559-66. 2005.


Exposure to bisphenol a during gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of rats.
Funabashi, T.,Kawaguchi, M., Furuta, M., Fukushima, A. and Kimura, F.
Psychoneuroendocrinology 29(4): 475-85. 2004.


Butyl benzyl phthalate, an endocrine disrupter, inhibits pulsatile luteinizing hormone secretion under an insulin-induced hypoglycaemic state in ovariectomized rats.
Kawaguchi, M., Funabashi, T., Aiba, S. and Kimura, F.
Journal of Neuroendocrinology 14(6): 486-91. 2002.


Effects of gestational and lactational exposure to bisphenol A on the hypothalamic control mechanism of reproduction in female rats.
雌性ラットの生殖機能調節中枢におよぼす、胎生期から授乳期にかけての内分泌撹乱物質ビスフェノールＡ曝露の影響.
Kawaguchi, M., Funabashi, T., Mitsushima, D.and Kimura, F.
Department of Physiology, Yokohama City University School of Medicine 52, 115-126. 2001.


The endocrine disruptors butyl benzyl phthalate and bisphenol a increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats.
Funabashi, T., Kawaguchi, M. and Kimura, F.
Neuroendocrinology 74(2): 77-81. 2001.


Menstrual changes in sleep, rectal temperature and melatonin rhythms in a subject with premenstrual syndrome.
Shinohara, K., Uchiyama, M., Okawa, M., Saito, K., Kawaguchi, M., Funabashi, T. and Kimura, F.
Neuroscience Letters 281(2-3): 159-162. 2000.


Intravenous injections of nicotine decrease the pulsatile secretion of LH by inhibiting the gonadotropin-releasing hormone (GnRH) pulse generator activity in female rats.
Sano, A., Funabashi, T.,Kawaguchi, M., Shinohara, K. and Kimura, F.
Psychoneuroendocrinology 24(4): 397-407. 1999.


Insulin-induced hypoglycemia does not impair the surge of luteinizing hormone secretion in the proestrous rat.
Kawaguchi, M., Funabashi, T. and Kimura, F.
Neuroscience Letters 256(3): 131-4. 1998.


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